Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury
نویسندگان
چکیده
منابع مشابه
The Podocyte in Diabetic Kidney Disease
Approaching epidemic levels, diabetic kidney disease (DKD) is now the leading cause of end-stage renal disease (ESRD). Microalbuminuria is an early clinical marker of DKD that results from damage to the glomerular filtration barrier at the level of the highly differentiated glomerular podocyte cells. Injury to these epithelial cells, podocytopathies, includes cellular hypertrophy, foot process ...
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26 Podocyte damage and accumulation of advanced glycation end-products (AGEs) are 27 characteristic of diabetic nephropathy (DN). The pathophysiology of AGE-challenged 28 podocytes such as hypertrophy, apoptosis and reduced cell migration is closely 29 related to the induction of cell cycle inhibitor p27 and to the inhibition of neuropilin 30 1 (NRP1). We previously demonstrated that treatment ...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2018
ISSN: 0085-2538
DOI: 10.1016/j.kint.2017.12.008